Signaling Pathways that Regulate Cell Division

Signaling pathways that regulate cell division.

Cell division requires careful orchestration of three major events: entry into mitosis, chromosomal segregation, and cytokinesis. Signaling within and between the molecules that control these events allows for their coordination via checkpoints, a specific class of signaling pathways that ensure the dependency of cell-cycle events on the successful completion of preceding events. Multiple posit...

Signaling networks that regulate cell migration.

SUMMARY Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control organization of the actin cytoskeleton and adhesion complexes. The Rho-family GTPases are a key convergence point of these pathways. Their effectors include actin regulators such as formins, members of the WASP/WAVE...

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.

Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular communication in the nervous system. The classical model for neurotransmitter action involves the uptake and storage of these small molecules into synaptic vesicles, release of vesicular contents into the synaptic cleft in response to depolarization of the presynaptic terminal by an action potential, bindin...

Signaling Pathways that Regulate Autophagic Muscle Protein Degradation in C

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Fibrillin microfibrils: connective tissue pathways that regulate shape and signaling.